Protein Modification Reagents
Medchemexpress LLC Pomalidomide-PEG2-azide | 2267306-14-7 | MFCD32198604 | 96.6% | 444.40 g/mol | C19H20N6O7 | 5 MG
Pomalidomide-PEG2-azide is a pomalidomide-based cereblon (CRBN) ligand-linker conjugate featuring a two-unit polyethylene glycol spacer and an azide functional group. It is developed as a building block for targeted protein degrader (PROTAC) research and for modular conjugation via click chemistry, offering a balance of solubility and reactivity for medicinal chemistry applications.
- Provides a pomalidomide scaffold for CRBN recruitment.
- Two-unit PEG linker improves solubility and linker flexibility.
- Azide handle enables copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Suitable for use as a PROTAC building block and linker module.
- Available in small-scale quantities for medicinal chemistry and assay development.
Medchemexpress LLC Fmoc-NH-PEG5-C2-NH2 | 2093277-71-3 | 98.1% | 502.60 g/mol | C27H38N2O7 | 5 MG
Fmoc-NH-PEG5-C2-NH2 is an Fmoc-protected PEG-based linker that provides a five-unit PEG spacer and a terminal primary amine for use in the synthesis of PROTACs and other bifunctional molecules. It is intended for medicinal chemistry applications where a flexible, hydrophilic linker and orthogonal protection are required.
- Provides a five-unit polyethylene glycol spacer for flexibility and solubility.
- Contains an Fmoc-protected amine for orthogonal deprotection strategies.
- Includes a terminal primary amine for straightforward coupling to ligands or linkers.
- Suitable for solution- or solid-phase synthesis workflows.
- High purity suitable for research-grade synthesis.
![eMolecules (S, R, S)-AHPC-PEG8-NHS ester | Broadpharm |980.140 | C46H69N5O16S | 98.000 | Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C(C)(C)C)cc1 | 250mg | 573896592](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183626.JPG-250.jpg)
eMolecules (S, R, S)-AHPC-PEG8-NHS ester | Broadpharm |980.140 | C46H69N5O16S | 98.000 | Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C(C)(C)C)cc1 | 250mg | 573896592
(S, R, S)-AHPC-PEG8-NHS ester | Broadpharm |980.140 | C46H69N5O16S | 98.000 | Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C(C)(C)C)cc1 | 250mg | 573896592
Medchemexpress LLC Mal-PEG5-NHS ester | 1807537-42-3 | 99.0% | 10 MG
Mal-PEG5-NHS ester is an Alkyl/ether and PEG-based PROTAC linker. It is used in the synthesis of PROTACs, which are composed of two different ligands connected by a linker. One ligand is for an E3 ubiquitin ligase and the other is for the target protein. PROTACs function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl/ether and PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits ubiquitin-proteasome system
- Selectively degrades target proteins